node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT35979.1 | AKT36181.1 | CMC5_000910 | CMC5_002950 | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | 0.649 |
AKT35979.1 | AKT37305.1 | CMC5_000910 | CMC5_014370 | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | Heat-shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.466 |
AKT35979.1 | AKT37306.1 | CMC5_000910 | CMC5_014380 | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | Heat-shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family. | 0.466 |
AKT35979.1 | AKT41211.1 | CMC5_000910 | CMC5_053720 | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | Spore protein SP21; Belongs to the small heat shock protein (HSP20) family. | 0.466 |
AKT35979.1 | clpP | CMC5_000910 | CMC5_048300 | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.708 |
AKT35979.1 | hrcA | CMC5_000910 | CMC5_000100 | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.822 |
AKT36181.1 | AKT35979.1 | CMC5_002950 | CMC5_000910 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.649 |
AKT36181.1 | AKT37305.1 | CMC5_002950 | CMC5_014370 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Heat-shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.630 |
AKT36181.1 | AKT37306.1 | CMC5_002950 | CMC5_014380 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Heat-shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family. | 0.630 |
AKT36181.1 | AKT38907.1 | CMC5_002950 | CMC5_030540 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Uncharacterized protein. | 0.767 |
AKT36181.1 | AKT41211.1 | CMC5_002950 | CMC5_053720 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Spore protein SP21; Belongs to the small heat shock protein (HSP20) family. | 0.681 |
AKT36181.1 | clpP | CMC5_002950 | CMC5_048300 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.864 |
AKT36181.1 | grpE | CMC5_002950 | CMC5_000040 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.649 |
AKT36181.1 | grxA | CMC5_002950 | CMC5_002960 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Glutaredoxin; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.659 |
AKT36181.1 | hrcA | CMC5_002950 | CMC5_000100 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.564 |
AKT36181.1 | ruvB | CMC5_002950 | CMC5_075910 | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.580 |
AKT37305.1 | AKT35979.1 | CMC5_014370 | CMC5_000910 | Heat-shock protein; Belongs to the small heat shock protein (HSP20) family. | Uncharacterized protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.466 |
AKT37305.1 | AKT36181.1 | CMC5_014370 | CMC5_002950 | Heat-shock protein; Belongs to the small heat shock protein (HSP20) family. | Protein disaggregation chaperone; Belongs to the ClpA/ClpB family. | 0.630 |
AKT37305.1 | AKT37306.1 | CMC5_014370 | CMC5_014380 | Heat-shock protein; Belongs to the small heat shock protein (HSP20) family. | Heat-shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family. | 0.760 |
AKT37305.1 | AKT41211.1 | CMC5_014370 | CMC5_053720 | Heat-shock protein; Belongs to the small heat shock protein (HSP20) family. | Spore protein SP21; Belongs to the small heat shock protein (HSP20) family. | 0.413 |