node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT36066.1 | AKT36612.1 | CMC5_001790 | CMC5_007320 | Homocysteine S-methyltransferase. | Uncharacterized protein. | 0.940 |
AKT36066.1 | AKT43151.1 | CMC5_001790 | CMC5_073810 | Homocysteine S-methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.997 |
AKT36066.1 | fmt | CMC5_001790 | CMC5_030280 | Homocysteine S-methyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.940 |
AKT36066.1 | folD | CMC5_001790 | CMC5_049210 | Homocysteine S-methyltransferase. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
AKT36066.1 | gcvT | CMC5_001790 | CMC5_035260 | Homocysteine S-methyltransferase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
AKT36066.1 | glyA | CMC5_001790 | CMC5_069780 | Homocysteine S-methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
AKT36066.1 | metG | CMC5_001790 | CMC5_016400 | Homocysteine S-methyltransferase. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.948 |
AKT36066.1 | purT | CMC5_001790 | CMC5_002370 | Homocysteine S-methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.942 |
AKT36612.1 | AKT36066.1 | CMC5_007320 | CMC5_001790 | Uncharacterized protein. | Homocysteine S-methyltransferase. | 0.940 |
AKT36612.1 | AKT43151.1 | CMC5_007320 | CMC5_073810 | Uncharacterized protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.917 |
AKT36612.1 | def-3 | CMC5_007320 | CMC5_041210 | Uncharacterized protein. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.710 |
AKT36612.1 | fmt | CMC5_007320 | CMC5_030280 | Uncharacterized protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.927 |
AKT36612.1 | folD | CMC5_007320 | CMC5_049210 | Uncharacterized protein. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
AKT36612.1 | gcvT | CMC5_007320 | CMC5_035260 | Uncharacterized protein. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.923 |
AKT36612.1 | glyA | CMC5_007320 | CMC5_069780 | Uncharacterized protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
AKT36612.1 | metG | CMC5_007320 | CMC5_016400 | Uncharacterized protein. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.935 |
AKT36612.1 | purT | CMC5_007320 | CMC5_002370 | Uncharacterized protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |
AKT36612.1 | sun | CMC5_007320 | CMC5_004810 | Uncharacterized protein. | Sun protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.824 |
AKT43151.1 | AKT36066.1 | CMC5_073810 | CMC5_001790 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase. | 0.997 |
AKT43151.1 | AKT36612.1 | CMC5_073810 | CMC5_007320 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Uncharacterized protein. | 0.917 |