node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT36066.1 | AKT43151.1 | CMC5_001790 | CMC5_073810 | Homocysteine S-methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.997 |
AKT36066.1 | fhs | CMC5_001790 | CMC5_039310 | Homocysteine S-methyltransferase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.953 |
AKT36066.1 | folD | CMC5_001790 | CMC5_049210 | Homocysteine S-methyltransferase. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
AKT36066.1 | gcvH | CMC5_001790 | CMC5_035250 | Homocysteine S-methyltransferase. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.477 |
AKT36066.1 | gcvP1 | CMC5_001790 | CMC5_035240 | Homocysteine S-methyltransferase. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.445 |
AKT36066.1 | gcvPB | CMC5_001790 | CMC5_011900 | Homocysteine S-methyltransferase. | Glycine dehydrogenase subunit 2. | 0.520 |
AKT36066.1 | gcvT | CMC5_001790 | CMC5_035260 | Homocysteine S-methyltransferase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
AKT36066.1 | glyA | CMC5_001790 | CMC5_069780 | Homocysteine S-methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
AKT43151.1 | AKT36066.1 | CMC5_073810 | CMC5_001790 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase. | 0.997 |
AKT43151.1 | fhs | CMC5_073810 | CMC5_039310 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.949 |
AKT43151.1 | folD | CMC5_073810 | CMC5_049210 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.492 |
AKT43151.1 | gcvH | CMC5_073810 | CMC5_035250 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.454 |
AKT43151.1 | gcvPB | CMC5_073810 | CMC5_011900 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase subunit 2. | 0.462 |
AKT43151.1 | gcvT | CMC5_073810 | CMC5_035260 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |
AKT43151.1 | glyA | CMC5_073810 | CMC5_069780 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
fhs | AKT36066.1 | CMC5_039310 | CMC5_001790 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Homocysteine S-methyltransferase. | 0.953 |
fhs | AKT43151.1 | CMC5_039310 | CMC5_073810 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.949 |
fhs | folD | CMC5_039310 | CMC5_049210 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
fhs | gcvH | CMC5_039310 | CMC5_035250 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.512 |
fhs | gcvPB | CMC5_039310 | CMC5_011900 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine dehydrogenase subunit 2. | 0.621 |