node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT36066.1 | AKT38772.1 | CMC5_001790 | CMC5_029180 | Homocysteine S-methyltransferase. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.424 |
AKT36066.1 | AKT43151.1 | CMC5_001790 | CMC5_073810 | Homocysteine S-methyltransferase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.997 |
AKT36066.1 | fhs | CMC5_001790 | CMC5_039310 | Homocysteine S-methyltransferase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.953 |
AKT36066.1 | folD | CMC5_001790 | CMC5_049210 | Homocysteine S-methyltransferase. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
AKT36066.1 | gcvT | CMC5_001790 | CMC5_035260 | Homocysteine S-methyltransferase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
AKT36066.1 | glyA | CMC5_001790 | CMC5_069780 | Homocysteine S-methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
AKT36066.1 | purH | CMC5_001790 | CMC5_048270 | Homocysteine S-methyltransferase. | Purine biosynthesis protein purH. | 0.945 |
AKT36066.1 | purT | CMC5_001790 | CMC5_002370 | Homocysteine S-methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.942 |
AKT38772.1 | AKT36066.1 | CMC5_029180 | CMC5_001790 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Homocysteine S-methyltransferase. | 0.424 |
AKT38772.1 | fhs | CMC5_029180 | CMC5_039310 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.777 |
AKT38772.1 | folD | CMC5_029180 | CMC5_049210 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.582 |
AKT38772.1 | glyA | CMC5_029180 | CMC5_069780 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.721 |
AKT38772.1 | purF | CMC5_029180 | CMC5_050510 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.412 |
AKT38772.1 | purH | CMC5_029180 | CMC5_048270 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Purine biosynthesis protein purH. | 0.470 |
AKT43151.1 | AKT36066.1 | CMC5_073810 | CMC5_001790 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase. | 0.997 |
AKT43151.1 | fhs | CMC5_073810 | CMC5_039310 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.949 |
AKT43151.1 | folD | CMC5_073810 | CMC5_049210 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.492 |
AKT43151.1 | gcvT | CMC5_073810 | CMC5_035260 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |
AKT43151.1 | glyA | CMC5_073810 | CMC5_069780 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
AKT43151.1 | purH | CMC5_073810 | CMC5_048270 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Purine biosynthesis protein purH. | 0.912 |