node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT36066.1 | AKT36612.1 | CMC5_001790 | CMC5_007320 | Homocysteine S-methyltransferase. | Uncharacterized protein. | 0.940 |
AKT36066.1 | fhs | CMC5_001790 | CMC5_039310 | Homocysteine S-methyltransferase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.953 |
AKT36066.1 | fmt | CMC5_001790 | CMC5_030280 | Homocysteine S-methyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.940 |
AKT36066.1 | folD | CMC5_001790 | CMC5_049210 | Homocysteine S-methyltransferase. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
AKT36066.1 | gcvT | CMC5_001790 | CMC5_035260 | Homocysteine S-methyltransferase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.959 |
AKT36066.1 | glyA | CMC5_001790 | CMC5_069780 | Homocysteine S-methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
AKT36066.1 | purD | CMC5_001790 | CMC5_083290 | Homocysteine S-methyltransferase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.438 |
AKT36066.1 | purH | CMC5_001790 | CMC5_048270 | Homocysteine S-methyltransferase. | Purine biosynthesis protein purH. | 0.945 |
AKT36066.1 | purT | CMC5_001790 | CMC5_002370 | Homocysteine S-methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.942 |
AKT36066.1 | purU | CMC5_001790 | CMC5_001990 | Homocysteine S-methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.944 |
AKT36612.1 | AKT36066.1 | CMC5_007320 | CMC5_001790 | Uncharacterized protein. | Homocysteine S-methyltransferase. | 0.940 |
AKT36612.1 | fmt | CMC5_007320 | CMC5_030280 | Uncharacterized protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.927 |
AKT36612.1 | folD | CMC5_007320 | CMC5_049210 | Uncharacterized protein. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
AKT36612.1 | gcvT | CMC5_007320 | CMC5_035260 | Uncharacterized protein. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.923 |
AKT36612.1 | glyA | CMC5_007320 | CMC5_069780 | Uncharacterized protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
AKT36612.1 | purT | CMC5_007320 | CMC5_002370 | Uncharacterized protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |
fhs | AKT36066.1 | CMC5_039310 | CMC5_001790 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Homocysteine S-methyltransferase. | 0.953 |
fhs | folD | CMC5_039310 | CMC5_049210 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
fhs | gcvT | CMC5_039310 | CMC5_035260 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
fhs | glyA | CMC5_039310 | CMC5_069780 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |