KXG76405.1 protein (Thermotalea metallivorans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KXG76405.1

Hypothetical protein. (80 aa)

Predicted Functional Partners:

por_1

0.862

por_2

0.862

KXG77483.1

0.691

ndoA

0.691

mazF

0.691

KXG76406.1

0.628

KXG74926.1

0.616

uviA

0.572

KXG78958.1

0.492

fliJ

0.485

Your Current Organism:

Thermotalea metallivorans

NCBI taxonomy Id: 520762
Other names: Clostridiaceae bacterium B2-1, DSM 21119, JCM 15105, KCTC 5625, T. metallivorans, Thermotalea metallivorans Ogg and Patel 2009, strain B2-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KXG74926.1	KXG76405.1	AN619_20250	AN619_09360	Hypothetical protein.	Hypothetical protein.	0.616
KXG74926.1	KXG78958.1	AN619_20250	AN619_01180	Hypothetical protein.	Hypothetical protein.	0.472
KXG74926.1	fliJ	AN619_20250	AN619_15010	Hypothetical protein.	Flagellar FliJ protein.	0.445
KXG76405.1	KXG74926.1	AN619_09360	AN619_20250	Hypothetical protein.	Hypothetical protein.	0.616
KXG76405.1	KXG76406.1	AN619_09360	AN619_09370	Hypothetical protein.	Hypothetical protein.	0.628
KXG76405.1	KXG77483.1	AN619_09360	AN619_04680	Hypothetical protein.	Hypothetical protein.	0.691
KXG76405.1	KXG78958.1	AN619_09360	AN619_01180	Hypothetical protein.	Hypothetical protein.	0.492
KXG76405.1	fliJ	AN619_09360	AN619_15010	Hypothetical protein.	Flagellar FliJ protein.	0.485
KXG76405.1	mazF	AN619_09360	AN619_24430	Hypothetical protein.	mRNA interferase MazF.	0.691
KXG76405.1	ndoA	AN619_09360	AN619_23500	Hypothetical protein.	mRNA interferase EndoA; Toxic component of a type II toxin-antitoxin (TA) system.	0.691
KXG76405.1	por_1	AN619_09360	AN619_01900	Hypothetical protein.	Pyruvate synthase.	0.862
KXG76405.1	por_2	AN619_09360	AN619_03950	Hypothetical protein.	Pyruvate synthase.	0.862
KXG76405.1	uviA	AN619_09360	AN619_30650	Hypothetical protein.	Bacteriocin UviA.	0.572
KXG76406.1	KXG76405.1	AN619_09370	AN619_09360	Hypothetical protein.	Hypothetical protein.	0.628
KXG77483.1	KXG76405.1	AN619_04680	AN619_09360	Hypothetical protein.	Hypothetical protein.	0.691
KXG78958.1	KXG74926.1	AN619_01180	AN619_20250	Hypothetical protein.	Hypothetical protein.	0.472
KXG78958.1	KXG76405.1	AN619_01180	AN619_09360	Hypothetical protein.	Hypothetical protein.	0.492
KXG78958.1	uviA	AN619_01180	AN619_30650	Hypothetical protein.	Bacteriocin UviA.	0.422
fliJ	KXG74926.1	AN619_15010	AN619_20250	Flagellar FliJ protein.	Hypothetical protein.	0.445
fliJ	KXG76405.1	AN619_15010	AN619_09360	Flagellar FliJ protein.	Hypothetical protein.	0.485

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.915

expected number of edges:

25

PPI enrichment p-value:

3.41e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 121

1.37

2.32

1.11e-10

GO:0009987

Cellular process

11 of 1128

0.44

0.37

0.00061

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

8 of 61

1.57

2.73

2.61e-09

GO:0019843

rRNA binding

5 of 33

1.63

2.02

9.98e-06

GO:0003723

RNA binding

6 of 97

1.24

1.35

4.02e-05

GO:0003676

Nucleic acid binding

9 of 306

0.92

0.95

6.56e-06

GO:0003746

Translation elongation factor activity

2 of 7

1.91

0.89

0.0202

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

8 of 64

1.55

2.74

1.02e-09

GO:0044391

Ribosomal subunit

4 of 21

1.73

2.06

1.79e-05

GO:0015934

Large ribosomal subunit

3 of 10

1.93

1.89

0.00013

GO:0022625

Cytosolic large ribosomal subunit

2 of 3

2.28

1.53

0.0013

GO:0005829

Cytosol

4 of 97

1.07

0.84

0.0025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:298

Ribosome

9 of 53

1.68

3.67

1.35e-12

CL:285

Ribosome, and Translation regulator activity

10 of 76

1.57

3.27

9.10e-13

CL:299

rRNA binding

6 of 31

1.74

2.88

3.58e-08

CL:300

rRNA-binding, and Ribosomal protein S5 domain 2-type fold, subgroup

5 of 26

1.74

2.43

1.27e-06

CL:276

Gene expression, and Helicase activity

11 of 144

1.34

2.38

9.10e-13

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

nvn03010

Ribosome

8 of 62

1.56

2.83

5.55e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

3 of 22

1.59

1.11

0.0041

GOCC:1990904

Ribonucleoprotein complex

3 of 37

1.36

0.86

0.0109

GOCC:0044391

Ribosomal subunit

2 of 14

1.61

0.77

0.0278

GOCC:0022626

Cytosolic ribosome

2 of 14

1.61

0.77

0.0278

GOCC:0043229

Intracellular organelle

7 of 270

0.87

0.71

0.0011

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

8 of 62

1.56

2.78

1.00e-09

KW-0699

rRNA-binding

5 of 29

1.69

2.27

2.52e-06

KW-0251

Elongation factor

2 of 5

2.06

1.13

0.0072

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01248

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

2 of 2

2.45

0.92

0.0208

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