KXG73646.1 protein (Thermotalea metallivorans)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

KXG73646.1

Small, acid-soluble spore protein alpha. (69 aa)

Predicted Functional Partners:

gpr

0.790

spoIIE

0.707

spoVAD_2

0.701

KXG74206.1

0.681

KXG75945.1

0.639

KXG74079.1

0.628

KXG75805.1

0.619

sigE

0.615

KXG74208.1

0.615

sigF_2

0.614

Your Current Organism:

Thermotalea metallivorans

NCBI taxonomy Id: 520762
Other names: Clostridiaceae bacterium B2-1, DSM 21119, JCM 15105, KCTC 5625, T. metallivorans, Thermotalea metallivorans Ogg and Patel 2009, strain B2-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KXG73646.1	KXG74079.1	AN619_30140	AN619_25940	Small, acid-soluble spore protein alpha.	Hypothetical protein.	0.628
KXG73646.1	KXG74206.1	AN619_30140	AN619_25240	Small, acid-soluble spore protein alpha.	Hypothetical protein.	0.681
KXG73646.1	KXG74208.1	AN619_30140	AN619_25260	Small, acid-soluble spore protein alpha.	Hypothetical protein.	0.615
KXG73646.1	KXG75805.1	AN619_30140	AN619_15590	Small, acid-soluble spore protein alpha.	Hypothetical protein.	0.619
KXG73646.1	KXG75945.1	AN619_30140	AN619_14080	Small, acid-soluble spore protein alpha.	Hypothetical protein.	0.639
KXG73646.1	gpr	AN619_30140	AN619_30610	Small, acid-soluble spore protein alpha.	Germination protease; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.	0.790
KXG73646.1	sigE	AN619_30140	AN619_14010	Small, acid-soluble spore protein alpha.	RNA polymerase sigma-35 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.615
KXG73646.1	sigF_2	AN619_30140	AN619_14020	Small, acid-soluble spore protein alpha.	RNA polymerase sigma-F factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.614
KXG73646.1	spoIIE	AN619_30140	AN619_27200	Small, acid-soluble spore protein alpha.	Stage II sporulation protein E.	0.707
KXG73646.1	spoVAD_2	AN619_30140	AN619_25250	Small, acid-soluble spore protein alpha.	Stage V sporulation protein AD.	0.701
KXG74079.1	KXG73646.1	AN619_25940	AN619_30140	Hypothetical protein.	Small, acid-soluble spore protein alpha.	0.628
KXG74079.1	KXG75945.1	AN619_25940	AN619_14080	Hypothetical protein.	Hypothetical protein.	0.424
KXG74079.1	spoIIE	AN619_25940	AN619_27200	Hypothetical protein.	Stage II sporulation protein E.	0.543
KXG74206.1	KXG73646.1	AN619_25240	AN619_30140	Hypothetical protein.	Small, acid-soluble spore protein alpha.	0.681
KXG74206.1	KXG74208.1	AN619_25240	AN619_25260	Hypothetical protein.	Hypothetical protein.	0.828
KXG74206.1	KXG75945.1	AN619_25240	AN619_14080	Hypothetical protein.	Hypothetical protein.	0.684
KXG74206.1	gpr	AN619_25240	AN619_30610	Hypothetical protein.	Germination protease; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.	0.775
KXG74206.1	sigE	AN619_25240	AN619_14010	Hypothetical protein.	RNA polymerase sigma-35 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.774
KXG74206.1	sigF_2	AN619_25240	AN619_14020	Hypothetical protein.	RNA polymerase sigma-F factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.771
KXG74206.1	spoIIE	AN619_25240	AN619_27200	Hypothetical protein.	Stage II sporulation protein E.	0.671

page 1 of 5

Network Stats

number of nodes:

5

number of edges:

8

average node degree:

3.2

avg. local clustering coefficient:

0.867

expected number of edges:

4

PPI enrichment p-value:

0.0581

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

4 of 12

1.84

1.58

0.00052

GO:0034654

Nucleobase-containing compound biosynthetic process

5 of 121

0.93

0.5

0.0423

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.14

2.25

3.45e-05

GO:0016779

Nucleotidyltransferase activity

5 of 69

1.17

0.99

0.0012

GO:0003677

DNA binding

7 of 182

0.9

0.75

0.00086

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 196

0.87

0.71

0.0011

GO:1901363

Heterocyclic compound binding

9 of 653

0.45

0.31

0.0306

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 7

2.07

2.42

1.14e-05

GO:0032991

Protein-containing complex

5 of 191

0.73

0.46

0.0229

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:289

RNA polymerase, and Nucleotide excision repair

6 of 7

2.25

4.17

2.06e-09

CL:97

Ribosome, and Protein export

8 of 105

1.2

1.48

1.07e-06

CL:618

Mixed, incl. WD40-repeat-containing domain superfamily, and ANK repeat

3 of 16

1.59

1.1

0.0044

CL:620

Mixed, incl. WD40-repeat-containing domain superfamily, and ANK repeat

2 of 7

1.77

0.77

0.0315

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 4

2.31

2.9

2.18e-06

map03420

Nucleotide excision repair

3 of 13

1.68

1.24

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 44

1.27

1.06

0.0014

MAP-5663205

Infectious disease

4 of 47

1.24

1.04

0.0014

MAP-1643685

Disease

4 of 52

1.2

1.0

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031931

TORC1 complex

3 of 5

2.09

1.55

0.0010

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 28

1.47

1.25

0.0010

GOCC:0032991

Protein-containing complex

8 of 367

0.65

0.51

0.0019

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 7

2.07

2.32

1.96e-05

KW-0548

Nucleotidyltransferase

5 of 36

1.46

1.58

6.43e-05

KW-0853

WD repeat

2 of 2

2.31

1.18

0.0064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036322

WD40-repeat-containing domain superfamily

3 of 4

2.19

1.35

0.0028

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

3 of 4

2.19

1.35

0.0028

IPR001680

WD40 repeat

2 of 2

2.31

0.76

0.0412

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

2 of 2

2.31

1.08

0.0102

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