STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhAL-serine dehydratase, alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (288 aa)    
Predicted Functional Partners:
sdhB
L-serine dehydratase, beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family.
 
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.949
tdcB_2
L-threonine ammonia-lyase.
  
 
 0.922
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.889
cysE
Serine acetyltransferase.
     
 0.880
hom
Homoserine dehydrogenase.
   
 
  0.879
pspA
Phosphoserine phosphatase 1; Belongs to the phosphoglycerate mutase family.
  
 
  0.879
tdcB_1
L-threonine dehydratase catabolic TdcB.
  
 
 0.788
dctA
C4-dicarboxylate transport protein; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
  
    0.755
ppaT
Pyridoxamine--pyruvate transaminase.
    
  0.668
Your Current Organism:
Fervidicola ferrireducens
NCBI taxonomy Id: 520764
Other names: DSM 21121, F. ferrireducens, Fervidicola ferrireducens Ogg and Patel 2009, JCM 15106, KCTC 5610, Thermoanaerobacteriaceae bacterium Y170, strain Y170
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