STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
thiEThiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (208 aa)    
Predicted Functional Partners:
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
 0.999
thiD
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 0.999
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
 0.994
thiH
2-iminoacetate synthase.
  
  
 0.925
KXG78672.1
Hypothetical protein.
  
 
 0.840
moeZ
Putative adenylyltransferase/sulfurtransferase MoeZ.
  
 
 0.840
KXG76619.1
Hypothetical protein.
  
 
 0.840
phoB
Alkaline phosphatase 3; Belongs to the alkaline phosphatase family.
    
  0.754
cdr
Coenzyme A disulfide reductase; Belongs to the sulfur carrier protein TusA family.
     
 0.741
thi4
Putative thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
     
 0.712
Your Current Organism:
Fervidicola ferrireducens
NCBI taxonomy Id: 520764
Other names: DSM 21121, F. ferrireducens, Fervidicola ferrireducens Ogg and Patel 2009, JCM 15106, KCTC 5610, Thermoanaerobacteriaceae bacterium Y170, strain Y170
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