KYO65352.1 protein (Thermovenabulum gondwanense)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

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Score

KYO65352.1

Hypothetical protein. (496 aa)

Predicted Functional Partners:

KYO66330.1

0.652

KYO66533.1

0.644

KYO66579.1

0.568

yjlD

0.545

lytB_1

0.500

KYO65152.1

0.441

ypeB

0.425

KYO66139.1

0.424

KYO65351.1

0.416

ssuA

0.410

Your Current Organism:

Thermovenabulum gondwanense

NCBI taxonomy Id: 520767
Other names: DSM 21133, KCTC 5616, T. gondwanense, Thermovenabulum gondwanense Ogg et al. 2010 emend. Pradel et al. 2013, Thermovenabulum sp. R270, strain R270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KYO65152.1	KYO65352.1	ATZ99_17410	ATZ99_15860	Hypothetical protein.	Hypothetical protein.	0.441
KYO65152.1	lytB_1	ATZ99_17410	ATZ99_05630	Hypothetical protein.	Amidase enhancer.	0.588
KYO65152.1	ypeB	ATZ99_17410	ATZ99_18180	Hypothetical protein.	Sporulation protein YpeB.	0.519
KYO65351.1	KYO65352.1	ATZ99_15850	ATZ99_15860	Hypothetical protein.	Hypothetical protein.	0.416
KYO65351.1	yjlD	ATZ99_15850	ATZ99_11590	Hypothetical protein.	NADH dehydrogenase-like protein YjlD.	0.649
KYO65352.1	KYO65152.1	ATZ99_15860	ATZ99_17410	Hypothetical protein.	Hypothetical protein.	0.441
KYO65352.1	KYO65351.1	ATZ99_15860	ATZ99_15850	Hypothetical protein.	Hypothetical protein.	0.416
KYO65352.1	KYO66139.1	ATZ99_15860	ATZ99_13310	Hypothetical protein.	Hypothetical protein.	0.424
KYO65352.1	KYO66330.1	ATZ99_15860	ATZ99_12120	Hypothetical protein.	Hypothetical protein.	0.652
KYO65352.1	KYO66533.1	ATZ99_15860	ATZ99_11610	Hypothetical protein.	Hypothetical protein.	0.644
KYO65352.1	KYO66579.1	ATZ99_15860	ATZ99_12070	Hypothetical protein.	Hypothetical protein.	0.568
KYO65352.1	lytB_1	ATZ99_15860	ATZ99_05630	Hypothetical protein.	Amidase enhancer.	0.500
KYO65352.1	ssuA	ATZ99_15860	ATZ99_21140	Hypothetical protein.	Putative aliphatic sulfonates-binding protein.	0.410
KYO65352.1	yjlD	ATZ99_15860	ATZ99_11590	Hypothetical protein.	NADH dehydrogenase-like protein YjlD.	0.545
KYO65352.1	ypeB	ATZ99_15860	ATZ99_18180	Hypothetical protein.	Sporulation protein YpeB.	0.425
KYO66139.1	KYO65352.1	ATZ99_13310	ATZ99_15860	Hypothetical protein.	Hypothetical protein.	0.424
KYO66139.1	KYO66330.1	ATZ99_13310	ATZ99_12120	Hypothetical protein.	Hypothetical protein.	0.710
KYO66139.1	yjlD	ATZ99_13310	ATZ99_11590	Hypothetical protein.	NADH dehydrogenase-like protein YjlD.	0.610
KYO66330.1	KYO65352.1	ATZ99_12120	ATZ99_15860	Hypothetical protein.	Hypothetical protein.	0.652
KYO66330.1	KYO66139.1	ATZ99_12120	ATZ99_13310	Hypothetical protein.	Hypothetical protein.	0.710

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.759

expected number of edges:

12

PPI enrichment p-value:

1.89e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

10 of 193

2.09

6.44

2.37e-17

GO:0030433

Ubiquitin-dependent ERAD pathway

7 of 69

2.38

6.1

1.50e-13

GO:0035967

Cellular response to topologically incorrect protein

5 of 53

2.35

4.21

3.45e-09

GO:0030968

Endoplasmic reticulum unfolded protein response

3 of 22

2.51

2.58

1.41e-05

GO:0033554

Cellular response to stress

8 of 723

1.42

2.26

7.92e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031593

Polyubiquitin modification-dependent protein binding

3 of 18

2.6

2.28

6.06e-05

GO:0051787

Misfolded protein binding

3 of 24

2.48

2.17

8.87e-05

GO:0043130

Ubiquitin binding

3 of 34

2.32

1.98

0.00018

GO:0005515

Protein binding

9 of 1308

1.22

1.61

1.62e-07

GO:0005488

Binding

11 of 7450

0.55

0.46

0.00027

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034098

VCP-NPL4-UFD1 AAA ATPase complex

2 of 12

2.6

1.66

0.00090

GO:0005789

Endoplasmic reticulum membrane

5 of 546

1.34

1.33

0.00020

GO:0005783

Endoplasmic reticulum

6 of 765

1.27

1.25

0.00020

GO:0031090

Organelle membrane

7 of 1452

1.06

1.01

0.00020

GO:0098796

Membrane protein complex

3 of 522

1.14

0.56

0.0468

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14637

ERAD pathway, and Hedgehog ligand biogenesis

11 of 56

2.67

12.07

3.36e-26

CL:14642

ERAD pathway, and Preribosome binding

10 of 44

2.74

11.48

3.29e-24

CL:14696

Mixed, incl. UBX domain, and VCP-NPL4-UFD1 AAA ATPase complex

6 of 16

2.95

7.28

2.04e-14

CL:14699

Mixed, incl. UBX domain, and Doa10p ubiquitin ligase complex

5 of 11

3.04

6.11

4.77e-12

CL:14711

UBX domain

4 of 5

3.28

5.12

4.75e-10

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

10 of 288

1.92

5.54

4.94e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-532668

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

4 of 27

2.55

3.33

4.92e-07

MAP-382556

ABC-family proteins mediated transport

3 of 94

1.88

1.36

0.0019

MAP-446203

Asparagine N-linked glycosylation

4 of 247

1.59

1.32

0.0011

MAP-5689896

Ovarian tumor domain proteases

2 of 32

2.17

0.99

0.0141

MAP-9755511

KEAP1-NFE2L2 pathway

2 of 38

2.1

0.95

0.0167

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000839

Hrd1p ubiquitin ligase ERAD-L complex

3 of 10

2.86

2.65

1.41e-05

GOCC:0000151

Ubiquitin ligase complex

4 of 114

1.92

2.22

1.97e-05

GOCC:0005789

Endoplasmic reticulum membrane

5 of 205

1.77

2.13

1.41e-05

GOCC:0005783

Endoplasmic reticulum

5 of 367

1.51

1.75

2.70e-05

GOCC:0098796

Membrane protein complex

6 of 518

1.44

1.72

1.41e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

3 of 69

2.02

1.58

0.00077

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04511

Der1-like family

3 of 5

3.16

2.96

4.29e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001012

UBX domain

4 of 4

3.38

4.62

4.30e-09

IPR007599

Derlin

3 of 5

3.16

2.89

5.66e-06

IPR029071

Ubiquitin-like domain superfamily

4 of 49

2.29

2.68

5.94e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00166

Domain present in ubiquitin-regulatory proteins

4 of 4

3.38

5.16

4.33e-10

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