node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apar_0339 | guaA | Apar_0339 | Apar_0189 | KEGG: rbe:RBE_0861 peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase; PFAM: peptidyl-tRNA hydrolase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.612 |
Apar_0339 | pheT | Apar_0339 | Apar_1054 | KEGG: rbe:RBE_0861 peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase; PFAM: peptidyl-tRNA hydrolase. | KEGG: ppd:Ppro_2303 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.526 |
Apar_0339 | prfA | Apar_0339 | Apar_1310 | KEGG: rbe:RBE_0861 peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase; PFAM: peptidyl-tRNA hydrolase. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.587 |
Apar_0339 | tsaD | Apar_0339 | Apar_0181 | KEGG: rbe:RBE_0861 peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase; PFAM: peptidyl-tRNA hydrolase. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.451 |
Apar_0339 | ychF | Apar_0339 | Apar_0186 | KEGG: rbe:RBE_0861 peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase; PFAM: peptidyl-tRNA hydrolase. | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.766 |
Apar_0834 | guaA | Apar_0834 | Apar_0189 | IMP dehydrogenase; KEGG: scl:sce0088 inositol-5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.999 |
Apar_0834 | lepA | Apar_0834 | Apar_0801 | IMP dehydrogenase; KEGG: scl:sce0088 inositol-5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.532 |
Apar_0834 | pheT | Apar_0834 | Apar_1054 | IMP dehydrogenase; KEGG: scl:sce0088 inositol-5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. | KEGG: ppd:Ppro_2303 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.920 |
Apar_0834 | prfA | Apar_0834 | Apar_1310 | IMP dehydrogenase; KEGG: scl:sce0088 inositol-5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.438 |
Apar_0834 | tsaD | Apar_0834 | Apar_0181 | IMP dehydrogenase; KEGG: scl:sce0088 inositol-5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.405 |
Apar_0834 | ychF | Apar_0834 | Apar_0186 | IMP dehydrogenase; KEGG: scl:sce0088 inositol-5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.596 |
guaA | Apar_0339 | Apar_0189 | Apar_0339 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | KEGG: rbe:RBE_0861 peptidyl-tRNA hydrolase; TIGRFAM: peptidyl-tRNA hydrolase; PFAM: peptidyl-tRNA hydrolase. | 0.612 |
guaA | Apar_0834 | Apar_0189 | Apar_0834 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase; KEGG: scl:sce0088 inositol-5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. | 0.999 |
guaA | lepA | Apar_0189 | Apar_0801 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.538 |
guaA | pheT | Apar_0189 | Apar_1054 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | KEGG: ppd:Ppro_2303 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.965 |
guaA | rpsG | Apar_0189 | Apar_1165 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. | 0.659 |
guaA | rsmA | Apar_0189 | Apar_1084 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.569 |
guaA | topA | Apar_0189 | Apar_1093 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | DNA topoisomerase type IA central domain protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken s [...] | 0.552 |
guaA | tsaD | Apar_0189 | Apar_0181 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.863 |
guaA | ychF | Apar_0189 | Apar_0186 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.682 |