Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (308 aa)    
Predicted Functional Partners:
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
 
 0.999
panB
3-methyl-2-oxobutanoatehydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
 0.998
coaX
Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
  
 
 0.995
Tpau_0566
PFAM: Domain of unknown function DUF2520; Putative oxidoreductase/dehydrogenase, Rossmann-like domain; KEGG: rop:ROP_43300 hypothetical protein.
   
 0.968
Tpau_1616
KEGG: rop:ROP_60750 glutamate decarboxylase; TIGRFAM: glutamate decarboxylase; PFAM: Pyridoxal-dependent decarboxylase; Belongs to the group II decarboxylase family.
  
 
 0.939
coaA
TIGRFAM: pantothenate kinase; KEGG: rop:ROP_59190 pantothenate kinase.
     
 0.925
cmk
KEGG: nfa:nfa20120 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region.
      0.907
Tpau_0838
PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: msm:MSMEG_3555 hydrolase.
    
 0.905
Tpau_2576
Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
  
 0.903
Tpau_0447
PFAM: aminotransferase class-III; KEGG: msm:MSMEG_2450 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.900
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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