Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa)    
Predicted Functional Partners:
Tpau_4229
PFAM: Aldehyde Dehydrogenase; Proline dehydrogenase; KEGG: ckp:ckrop_0287 delta-1-pyrroline-5- carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 0.949
Tpau_1492
TIGRFAM: proline iminopeptidase; KEGG: rop:ROP_08970 prolyl aminopeptidase; PFAM: alpha/beta hydrolase fold; Belongs to the peptidase S33 family.
    
  0.901
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 
 0.900
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.892
Tpau_0659
KEGG: rop:ROP_17330 hypothetical protein.
       0.821
Tpau_3499
KEGG: nca:Noca_1780 D-amino-acid oxidase; PFAM: FAD dependent oxidoreductase.
  
 
 0.815
Tpau_0658
PFAM: Xylose isomerase domain protein TIM barrel; KEGG: rha:RHA1_ro02063 hypothetical protein.
       0.752
Tpau_0657
KEGG: rer:RER_16250 hypothetical protein.
       0.715
Tpau_0107
KEGG: rop:ROP_35350 glutamate synthase large subunit; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II.
     
 0.704
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.661
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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