Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_0670Porphobilinogen synthase; KEGG: rop:ROP_17220 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.998
Tpau_0669
PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: nfa:nfa51680 putative uroporphyrin-III C- methyltransferase/uroporphyrinogen-III synthase.
 
 
 0.997
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: nfa:nfa51600 glutamate-1-semialdehyde aminotransferase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III.
 
 
 0.990
Tpau_3948
PFAM: aminotransferase class-III; KEGG: bmr:BMI_II1109 glutamate-1-semialdehyde 2,1- aminomutase, putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.986
Tpau_0071
PFAM: aminotransferase class-III; C- methyltransferase; KEGG: rha:RHA1_ro05728 glutamate-1-semialdehyde 2,1- aminomutase.
 
 
 0.976
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.963
Tpau_1703
uroporphyrin-III C-methyltransferase; KEGG: nfa:nfa40770 putative uroporphyrinogen III methylase; TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
 
  
 0.942
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.869
Tpau_0672
KEGG: nfa:nfa51640 hypothetical protein.
  
    0.853
Tpau_0671
KEGG: rop:ROP_17210 hypothetical membrane protein.
       0.836
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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