Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_0895PFAM: Endonuclease/exonuclease/phosphatase; Twin- arginine translocation pathway, signal sequence, subgroup; KEGG: rer:RER_56610 hypothetical protein. (353 aa)    
Predicted Functional Partners:
Tpau_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.613
Tpau_0894
KEGG: rpa:RPA3869 XRE family transcriptional regulator; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein.
  
    0.588
Tpau_2371
KEGG: rop:ROP_06590 pseudouridine synthase; PFAM: pseudouridine synthase; RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; Belongs to the pseudouridine synthase RsuA family.
  
    0.558
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.515
Tpau_0436
KEGG: rop:ROP_15710 putative endonuclease IV; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2.
    
 
 0.484
Tpau_0595
HhH-GPD family protein; KEGG: nfa:nfa4290 putative A/G-specific adenine glycosylase; PFAM: HhH-GPD family protein; helix-hairpin-helix motif; iron-sulfur cluster loop; SMART: HhH-GPD family protein; iron-sulfur cluster loop.
    
 0.481
Tpau_1408
KEGG: nca:Noca_2964 HhH-GPD family protein; TIGRFAM: HhH-GPD family protein; PFAM: HhH-GPD family protein.
  
 0.474
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 0.474
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 0.458
Tpau_3470
KEGG: mab:MAB_0395c hypothetical protein.
   
 0.427
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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