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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Tpau_0907TIGRFAM: IMP dehydrogenase family protein; KEGG: rha:RHA1_ro06200 inosine 5-monophosphate dehydrogenase. (388 aa)    
Predicted Functional Partners:
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
 
 0.970
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
0.959
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.932
purH
SMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: rha:RHA1_ro05579 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein.
  
  
  0.912
Tpau_2316
TIGRFAM: IMP dehydrogenase family protein; KEGG: mgi:Mflv_3360 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein.
  
 
0.910
Tpau_0544
HAD-superfamily hydrolase, subfamily IIA; KEGG: rop:ROP_19480 putative NMP phosphatase; TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase domain protein hydrolase; Belongs to the HAD-like hydrolase superfamily.
   
 
 0.901
Tpau_1295
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.901
Tpau_2145
PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family.
    
  0.901
Tpau_0556
TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: mjl:Mjls_5161 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
  0.900
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
 
    0.657
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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