Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_0923KEGG: rop:ROP_62730 hypothetical protein. (527 aa)    
Predicted Functional Partners:
Tpau_0922
KEGG: rha:RHA1_ro06212 hypothetical protein.
 
  
 0.993
dnaE2
DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
 
  
 0.909
Tpau_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.734
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.657
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.614
Tpau_3046
KEGG: mab:MAB_3511c DNA helicase II; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein.
  
 0.583
lexA
Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
 
 0.572
Tpau_1217
PFAM: metallophosphoesterase; KEGG: mjl:Mjls_3950 metallophosphoesterase.
  
 0.520
Tpau_2686
DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: rha:RHA1_ro01126 hypothetical protein; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein.
 
  
 0.519
Tpau_0201
KEGG: mav:MAV_1056 ATP-dependent DNA ligase; TIGRFAM: DNA polymerase LigD, polymerase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase; DNA primase small subunit; ATP dependent DNA ligase domain protein; mRNA capping enzyme.
  
 
 0.505
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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