node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tpau_0970 | Tpau_0971 | Tpau_0970 | Tpau_0971 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | Integral membrane sensor signal transduction histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; KEGG: ami:Amir_0531 histidine kinase. | 0.551 |
Tpau_0970 | Tpau_0972 | Tpau_0970 | Tpau_0972 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | KEGG: saq:Sare_0423 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR. | 0.531 |
Tpau_0970 | Tpau_1230 | Tpau_0970 | Tpau_1230 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | KEGG: mab:MAB_1435 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. | 0.445 |
Tpau_0970 | Tpau_1832 | Tpau_0970 | Tpau_1832 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | Histone deacetylase; KEGG: rer:RER_28020 acetoin utilization protein; PFAM: histone deacetylase superfamily. | 0.473 |
Tpau_0970 | Tpau_2144 | Tpau_0970 | Tpau_2144 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.428 |
Tpau_0970 | Tpau_4007 | Tpau_0970 | Tpau_4007 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | KEGG: sen:SACE_0256 hypothetical protein. | 0.546 |
Tpau_0970 | aroC | Tpau_0970 | Tpau_2618 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.425 |
Tpau_0970 | glyA | Tpau_0970 | Tpau_3130 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.456 |
Tpau_0970 | leuB | Tpau_0970 | Tpau_2855 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.437 |
Tpau_0970 | serC | Tpau_0970 | Tpau_0847 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.683 |
Tpau_0971 | Tpau_0970 | Tpau_0971 | Tpau_0970 | Integral membrane sensor signal transduction histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; KEGG: ami:Amir_0531 histidine kinase. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | 0.551 |
Tpau_0971 | Tpau_0972 | Tpau_0971 | Tpau_0972 | Integral membrane sensor signal transduction histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; KEGG: ami:Amir_0531 histidine kinase. | KEGG: saq:Sare_0423 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR. | 0.961 |
Tpau_0972 | Tpau_0970 | Tpau_0972 | Tpau_0970 | KEGG: saq:Sare_0423 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | 0.531 |
Tpau_0972 | Tpau_0971 | Tpau_0972 | Tpau_0971 | KEGG: saq:Sare_0423 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR. | Integral membrane sensor signal transduction histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; KEGG: ami:Amir_0531 histidine kinase. | 0.961 |
Tpau_1230 | Tpau_0970 | Tpau_1230 | Tpau_0970 | KEGG: mab:MAB_1435 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | 0.445 |
Tpau_1230 | Tpau_2144 | Tpau_1230 | Tpau_2144 | KEGG: mab:MAB_1435 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.961 |
Tpau_1230 | aroC | Tpau_1230 | Tpau_2618 | KEGG: mab:MAB_1435 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.505 |
Tpau_1230 | leuB | Tpau_1230 | Tpau_2855 | KEGG: mab:MAB_1435 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.541 |
Tpau_1230 | serC | Tpau_1230 | Tpau_0847 | KEGG: mab:MAB_1435 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.601 |
Tpau_1832 | Tpau_0970 | Tpau_1832 | Tpau_0970 | Histone deacetylase; KEGG: rer:RER_28020 acetoin utilization protein; PFAM: histone deacetylase superfamily. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: svi:Svir_15320 phosphoglycerate dehydrogenase- like oxidoreductase. | 0.473 |