Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Tpau_1044KEGG: mva:Mvan_1722 biotin--acetyl-CoA-carboxylase ligase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; biotin protein ligase domain protein. (269 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.958
Tpau_1872
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; carboxyl transferase; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: rha:RHA1_ro02782 carboxylase.
 
 
 0.898
Tpau_0937
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
 
 
 0.873
Tpau_1317
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; carboxyl transferase; biotin/lipoyl attachment domain- containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: tfu:Tfu_1530 acetyl/propionyl-CoA carboxylase alpha subunit.
  
 
 0.840
Tpau_1045
PFAM: membrane-flanked domain; KEGG: msm:MSMEG_1818 membrane flanked domain- containing protein.
       0.828
Tpau_1031
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: rer:RER_21210 acyl-CoA carboxylase alpha chain.
 
  
 0.815
Tpau_1315
PFAM: MaoC domain protein dehydratase; Beta- ketoacyl synthase; Acyl transferase; domain of unknown function DUF1729; KEGG: nfa:nfa12570 putative fatty acid synthase.
  
  
 0.795
Tpau_1046
Two component transcriptional regulator, winged helix family; KEGG: rop:ROP_63600 putative OmpR family two- component response regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
     
 0.792
Tpau_3320
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: mgi:Mflv_2553 carbamoyl-phosphate synthase L chain, ATP-binding.
 
  
 0.781
Tpau_2829
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: rer:RER_17550 acyl-CoA carboxylase alpha chain.
 
  
 0.774
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
Server load: medium (42%) [HD]