| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Tpau_1047 | Tpau_1048 | Tpau_1047 | Tpau_1048 | Integral membrane sensor signal transduction histidine kinase; KEGG: rer:RER_21360 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein. | PFAM: GtrA family protein; KEGG: rha:RHA1_ro06298 hypothetical protein. | 0.761 |
| Tpau_1047 | Tpau_1051 | Tpau_1047 | Tpau_1051 | Integral membrane sensor signal transduction histidine kinase; KEGG: rer:RER_21360 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein. | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | 0.456 |
| Tpau_1047 | purE | Tpau_1047 | Tpau_1050 | Integral membrane sensor signal transduction histidine kinase; KEGG: rer:RER_21360 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.488 |
| Tpau_1047 | purK | Tpau_1047 | Tpau_1049 | Integral membrane sensor signal transduction histidine kinase; KEGG: rer:RER_21360 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.488 |
| Tpau_1048 | Tpau_1047 | Tpau_1048 | Tpau_1047 | PFAM: GtrA family protein; KEGG: rha:RHA1_ro06298 hypothetical protein. | Integral membrane sensor signal transduction histidine kinase; KEGG: rer:RER_21360 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein. | 0.761 |
| Tpau_1048 | Tpau_1051 | Tpau_1048 | Tpau_1051 | PFAM: GtrA family protein; KEGG: rha:RHA1_ro06298 hypothetical protein. | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | 0.503 |
| Tpau_1048 | purE | Tpau_1048 | Tpau_1050 | PFAM: GtrA family protein; KEGG: rha:RHA1_ro06298 hypothetical protein. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.670 |
| Tpau_1048 | purK | Tpau_1048 | Tpau_1049 | PFAM: GtrA family protein; KEGG: rha:RHA1_ro06298 hypothetical protein. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.670 |
| Tpau_1051 | Tpau_1047 | Tpau_1051 | Tpau_1047 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | Integral membrane sensor signal transduction histidine kinase; KEGG: rer:RER_21360 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein. | 0.456 |
| Tpau_1051 | Tpau_1048 | Tpau_1051 | Tpau_1048 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | PFAM: GtrA family protein; KEGG: rha:RHA1_ro06298 hypothetical protein. | 0.503 |
| Tpau_1051 | Tpau_1910 | Tpau_1051 | Tpau_1910 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ach:Achl_3375 glyoxalase/bleomycin resistance protein/dioxygenase. | 0.457 |
| Tpau_1051 | Tpau_3158 | Tpau_1051 | Tpau_3158 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: sco:SCO2813 hypothetical protein. | 0.452 |
| Tpau_1051 | Tpau_3871 | Tpau_1051 | Tpau_3871 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: ami:Amir_5078 bifunctional deaminase- reductase domain protein. | 0.512 |
| Tpau_1051 | purE | Tpau_1051 | Tpau_1050 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.708 |
| Tpau_1051 | purK | Tpau_1051 | Tpau_1049 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.708 |
| Tpau_1051 | thyA | Tpau_1051 | Tpau_1760 | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.495 |
| Tpau_1910 | Tpau_1051 | Tpau_1910 | Tpau_1051 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ach:Achl_3375 glyoxalase/bleomycin resistance protein/dioxygenase. | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | 0.457 |
| Tpau_1910 | Tpau_3871 | Tpau_1910 | Tpau_3871 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ach:Achl_3375 glyoxalase/bleomycin resistance protein/dioxygenase. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: ami:Amir_5078 bifunctional deaminase- reductase domain protein. | 0.544 |
| Tpau_3158 | Tpau_1051 | Tpau_3158 | Tpau_1051 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: sco:SCO2813 hypothetical protein. | KEGG: ach:Achl_0378 bifunctional deaminase- reductase domain protein. | 0.452 |
| Tpau_3158 | Tpau_3871 | Tpau_3158 | Tpau_3871 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: sco:SCO2813 hypothetical protein. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: ami:Amir_5078 bifunctional deaminase- reductase domain protein. | 0.723 |