Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Tpau_1077Integral membrane sensor signal transduction histidine kinase; KEGG: rha:RHA1_ro06325 sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein. (554 aa)    
Predicted Functional Partners:
Tpau_1076
Two component transcriptional regulator, winged helix family; KEGG: mjl:Mjls_1381 two component transcriptional regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
 
 0.997
Tpau_0098
Integral membrane sensor signal transduction histidine kinase; KEGG: rer:RER_19450 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein.
  
  
 
0.924
lpqB
PFAM: Lipoprotein LpqB, beta-propeller domain-like; Lipoprotein LpqB, GerMN domain; KEGG: rha:RHA1_ro06326 lipoprotein LpqB.
 
    0.870
Tpau_1079
KEGG: mab:MAB_3585c hypothetical protein.
 
    0.815
Tpau_1211
2-oxoglutarate dehydrogenase, E1 subunit; KEGG: rha:RHA1_ro06012 alpha-ketoglutarate decarboxylase; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes.
   
 0.799
Tpau_3286
Two component transcriptional regulator, winged helix family; KEGG: rer:RER_43980 two-component response regulator MprA; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
 
 
 0.768
Tpau_0654
Two component transcriptional regulator, winged helix family; KEGG: mjl:Mjls_0654 two component transcriptional regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
 
 
 0.766
Tpau_0093
Two component transcriptional regulator, winged helix family; KEGG: nca:Noca_0312 response regulator receiver; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
 
 
 0.746
Tpau_2015
Two component transcriptional regulator, winged helix family; KEGG: cmi:CMM_2335 putative two-component system response regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
 
 
 0.742
Tpau_1046
Two component transcriptional regulator, winged helix family; KEGG: rop:ROP_63600 putative OmpR family two- component response regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver.
 
 
 0.729
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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