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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
Tpau_1217PFAM: metallophosphoesterase; KEGG: mjl:Mjls_3950 metallophosphoesterase. (379 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.973
Tpau_1218
PFAM: SMC domain protein; KEGG: mav:MAV_1428 hypothetical protein.
 
 
 0.966
Tpau_3046
KEGG: mab:MAB_3511c DNA helicase II; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein.
  
 0.966
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.820
Tpau_1215
SNF2-related protein; KEGG: nfa:nfa10310 putative helicase; PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein.
  
 
 0.795
Tpau_0095
Carbonate dehydratase; KEGG: nfa:pnf1540 putative transporter; PFAM: sulphate transporter; carbonic anhydrase; Xanthine/uracil/vitamin C permease.
  
   0.794
Tpau_1940
KEGG: mlu:Mlut_03530 ATP-dependent DNA helicase RecQ; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein.
  
 0.791
Tpau_2173
KEGG: rop:ROP_05710 putative 5'-3' exonuclease; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2.
   
 0.784
Tpau_1280
SMART: helicase c2; DEAD-like helicase; KEGG: rer:RER_38870 ATP-dependent DNA helicase DinG.
 
 0.778
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.711
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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