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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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cobBPFAM: Silent information regulator protein Sir2; KEGG: mbt:JTY_1185 NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. (273 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.939
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.931
Tpau_1285
PFAM: isochorismatase hydrolase; KEGG: nfa:nfa10840 putative nicotinamidase.
 
 
 0.921
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.910
Tpau_3050
PFAM: NUDIX hydrolase; NADH pyrophosphatase-like; KEGG: nfa:nfa45350 NADH pyrophosphatase.
   
  0.909
Tpau_0191
KEGG: mva:Mvan_0120 NAD(P) transhydrogenase subunit alpha; TIGRFAM: NAD(P) transhydrogenase, alpha subunit; PFAM: alanine dehydrogenase/PNT domain protein.
    
 0.905
Tpau_0983
Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.905
Tpau_0192
NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.901
Tpau_3190
PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: msm:MSMEG_5422 nucleoside triphosphate pyrophosphohydrolase.
    
  0.901
Tpau_3046
KEGG: mab:MAB_3511c DNA helicase II; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein.
  
 
 0.842
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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