Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_1319KEGG: rop:ROP_03480 hypothetical protein. (145 aa)    
Predicted Functional Partners:
Tpau_1320
Transcriptional regulator, MerR family; KEGG: nfa:nfa22770 putative transcriptional regulator; PFAM: regulatory protein MerR; SMART: regulatory protein MerR.
 
     0.909
hisS
TIGRFAM: histidyl-tRNA synthetase; KEGG: nfa:nfa36640 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein.
    
  0.748
Tpau_1333
Hypothetical protein; KEGG: rha:RHA1_ro05481 protease.
  
 
 0.582
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
   
 
 0.561
Tpau_0394
KEGG: nfa:nfa8260 hypothetical protein; PFAM: AAA ATPase central domain protein; Tetratricopeptide TPR_4; SMART: AAA ATPase.
   
 0.498
Tpau_0407
Histidine kinase; KEGG: rer:RER_40240 two-component histidine kinase; PFAM: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SMART: ATP-binding region ATPase domain protein.
  
 
 0.498
Tpau_1752
KEGG: cai:Caci_2076 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; Belongs to the AAA ATPase family.
   
 0.498
Tpau_3711
Adenosinetriphosphatase; PFAM: AAA ATPase central domain protein; KEGG: rer:RER_15150 ATPase; SMART: AAA ATPase; Belongs to the AAA ATPase family.
   
 0.498
Tpau_0107
KEGG: rop:ROP_35350 glutamate synthase large subunit; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II.
      
 0.497
Tpau_4096
KEGG: mab:MAB_1644 hypothetical protein.
   
 
 0.484
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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