Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_1743TIGRFAM: alanine dehydrogenase; KEGG: mjl:Mjls_2087 L-alanine dehydrogenase; PFAM: alanine dehydrogenase/PNT domain protein; Belongs to the AlaDH/PNT family. (371 aa)    
Predicted Functional Partners:
Tpau_0878
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
 
 0.958
Tpau_0192
NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
      0.906
Tpau_0461
PFAM: aminotransferase class I and II; KEGG: rer:RER_13320 alanine aminotransferase.
     
 0.906
Tpau_0992
Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: nfa:nfa9700 putative aminotransferase.
    
 0.900
Tpau_2490
TIGRFAM: pyruvate kinase; KEGG: rha:RHA1_ro01007 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family.
     
 0.827
Tpau_0284
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: msm:MSMEG_3964 pyruvate dehydrogenase; Belongs to the TPP enzyme family.
     
 0.812
Tpau_0099
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
    
  0.802
Tpau_2722
2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.802
Tpau_0758
KEGG: nfa:nfa32960 putative L-lactate dehydrogenase; PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase.
     
  0.800
Tpau_0937
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
  0.800
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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