Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_2040PFAM: inositol monophosphatase; KEGG: rop:ROP_07490 putative inositol monophosphatase ImpA. (287 aa)    
Predicted Functional Partners:
hisA
TIGRFAM: bifunctional HisA/TrpF protein; KEGG: rop:ROP_07500 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino) methylideneamino] imidazole-4- carboxamide isomerase; PFAM: histidine biosynthesis protein.
  
  
 0.978
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.967
Tpau_4195
KEGG: rer:RER_58450 myo-inositol-1-phosphate synthase; TIGRFAM: inositol 1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; Myo- inositol-1-phosphate synthase GAPDH domain protein.
  
 
 0.953
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.934
Tpau_1921
PFAM: CDP-alcohol phosphatidyltransferase; KEGG: rer:RER_29050 phosphatidylinositol synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
 
 0.933
Tpau_1880
PFAM: inositol monophosphatase; KEGG: rop:ROP_68100 inositol monophosphatase SuhB.
  
  
0.930
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.912
Tpau_1361
Inositol 2-dehydrogenase; KEGG: cgt:cgR_2947 hypothetical protein; PFAM: oxidoreductase domain protein; Oxidoreductase domain.
    
 0.905
Tpau_2452
Phospholipase C; KEGG: rer:RER_56920 phospholipase C; PFAM: phosphoesterase; protein of unknown function DUF756.
     
  0.900
Tpau_2038
KEGG: rer:RER_34460 hypothetical protein.
       0.794
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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