Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_2091Band 7 protein; KEGG: rop:ROP_70070 stomatin family protein; PFAM: band 7 protein; SMART: band 7 protein. (401 aa)    
Predicted Functional Partners:
Tpau_2090
PFAM: protein of unknown function DUF107; KEGG: rop:ROP_70060 hypothetical membrane protein.
 
 
 0.954
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.832
Tpau_1739
PFAM: peptidase M16 domain protein; KEGG: rha:RHA1_ro06734 metalloendopeptidase; Belongs to the peptidase M16 family.
  
 0.692
Tpau_2287
PFAM: band 7 protein; KEGG: rer:RER_05390 hypothetical protein.
    
 0.662
Tpau_4219
PFAM: protein of unknown function DUF179; KEGG: mmi:MMAR_0053 hypothetical protein; Belongs to the UPF0301 (AlgH) family.
  
    0.623
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 
 0.602
Tpau_1537
PFAM: cytochrome c oxidase subunit II; KEGG: nfa:nfa17080 putative cytochrome c oxidase subunit II.
   
 
 0.589
Tpau_3118
KEGG: mbt:JTY_1133 hypothetical protein.
   
    0.547
Tpau_3863
Band 7 protein; KEGG: cef:CE2656 hypothetical protein; PFAM: band 7 protein; SMART: band 7 protein.
      
 0.535
Tpau_1222
KEGG: nfa:nfa17840 putative transporter ATPase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase.
 
 
 0.524
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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