Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_216020S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (242 aa)    
Predicted Functional Partners:
Tpau_2159
20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.999
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
 0.991
Tpau_4099
PFAM: Protein of unknown function DUF2587; KEGG: rer:RER_02610 hypothetical protein.
  
 
 
 0.980
pup
Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family.
 
   
 0.966
pafA
Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
   
 0.943
Tpau_2155
PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor.
   
 0.836
Tpau_1005
PFAM: Carbohydrate kinase, FGGY-like; KEGG: rop:ROP_63250 glycerol kinase.
   
 0.785
Tpau_1289
Mov34/MPN/PAD-1 family protein; KEGG: sen:SACE_1204 Mov34/MPN/PAD-1; PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein.
   
 0.764
Tpau_2157
KEGG: tfu:Tfu_2225 hypothetical protein.
       0.541
Tpau_3765
KEGG: rop:ROP_61020 putative ABC transporter permease/ATP-binding protein; PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase.
  
 
  0.524
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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