Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_2261TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: rha:RHA1_ro00618 isocitrate dehydrogenase (NADP+); PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family. (745 aa)    
Predicted Functional Partners:
Tpau_1211
2-oxoglutarate dehydrogenase, E1 subunit; KEGG: rha:RHA1_ro06012 alpha-ketoglutarate decarboxylase; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes.
   
 
 0.951
Tpau_2075
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.944
Tpau_0107
KEGG: rop:ROP_35350 glutamate synthase large subunit; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II.
     
 0.914
Tpau_3624
TIGRFAM: adenylosuccinate lyase; KEGG: rer:RER_10250 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
  0.825
Tpau_1385
PFAM: NAD-glutamate dehydrogenase; KEGG: nfa:nfa13060 putative NAD-dependent glutamate dehydrogenase.
   
 
 0.815
argH
KEGG: nfa:nfa19630 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase.
    
 0.811
Tpau_0108
KEGG: nfa:nfa970 glutamate synthase subunit beta; TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
   
 
 0.806
Tpau_2011
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
    
  0.803
Tpau_0115
PFAM: Aldehyde Dehydrogenase; KEGG: rha:RHA1_ro03944 succinic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
     
 0.800
Tpau_0356
PFAM: fumarate lyase; Fumarase C-like; KEGG: aau:AAur_3794 aspartate ammonia-lyase.
     
  0.800
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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