node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tpau_0178 | Tpau_2144 | Tpau_0178 | Tpau_2144 | PFAM: GAF domain protein; KEGG: xfn:XfasM23_0503 putative GAF sensor protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
Tpau_0178 | metK | Tpau_0178 | Tpau_2575 | PFAM: GAF domain protein; KEGG: xfn:XfasM23_0503 putative GAF sensor protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
Tpau_1588 | metK | Tpau_1588 | Tpau_2575 | KEGG: bln:Blon_0092 DNA-cytosine methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.920 |
Tpau_2144 | Tpau_0178 | Tpau_2144 | Tpau_0178 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: GAF domain protein; KEGG: xfn:XfasM23_0503 putative GAF sensor protein. | 0.900 |
Tpau_2144 | Tpau_2908 | Tpau_2144 | Tpau_2908 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Methionine synthase vitamin-B12 independent; KEGG: rer:RER_23790 hypothetical protein. | 0.819 |
Tpau_2144 | metK | Tpau_2144 | Tpau_2575 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.971 |
Tpau_2144 | priA | Tpau_2144 | Tpau_2574 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.402 |
Tpau_2564 | Tpau_2576 | Tpau_2564 | Tpau_2576 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: rha:RHA1_ro07167 ribulose-phosphate 3- epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.578 |
Tpau_2564 | gmk | Tpau_2564 | Tpau_2578 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: rha:RHA1_ro07167 ribulose-phosphate 3- epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.774 |
Tpau_2564 | metK | Tpau_2564 | Tpau_2575 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: rha:RHA1_ro07167 ribulose-phosphate 3- epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.806 |
Tpau_2564 | priA | Tpau_2564 | Tpau_2574 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: rha:RHA1_ro07167 ribulose-phosphate 3- epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.440 |
Tpau_2564 | ribH | Tpau_2564 | Tpau_2560 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: rha:RHA1_ro07167 ribulose-phosphate 3- epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.639 |
Tpau_2576 | Tpau_2564 | Tpau_2576 | Tpau_2564 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: rha:RHA1_ro07167 ribulose-phosphate 3- epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.578 |
Tpau_2576 | gmk | Tpau_2576 | Tpau_2578 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.836 |
Tpau_2576 | metK | Tpau_2576 | Tpau_2575 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.863 |
Tpau_2576 | priA | Tpau_2576 | Tpau_2574 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.848 |
Tpau_2576 | ribH | Tpau_2576 | Tpau_2560 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.465 |
Tpau_2908 | Tpau_2144 | Tpau_2908 | Tpau_2144 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: rer:RER_23790 hypothetical protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.819 |
Tpau_2908 | metK | Tpau_2908 | Tpau_2575 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: rer:RER_23790 hypothetical protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.863 |
Tpau_2908 | priA | Tpau_2908 | Tpau_2574 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: rer:RER_23790 hypothetical protein. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.560 |