Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Tpau_2642PFAM: protein of unknown function DUF152; KEGG: rha:RHA1_ro01084 hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. (253 aa)    
Predicted Functional Partners:
Tpau_0556
TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: mjl:Mjls_5161 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
  0.918
Tpau_2641
Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
  
 0.908
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
  0.907
mtnP
Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
    
  0.902
add
TIGRFAM: adenosine deaminase; KEGG: nfa:nfa9530 adenosine deaminase; PFAM: adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
    
 0.902
Tpau_0983
Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
  0.902
Tpau_0544
HAD-superfamily hydrolase, subfamily IIA; KEGG: rop:ROP_19480 putative NMP phosphatase; TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase domain protein hydrolase; Belongs to the HAD-like hydrolase superfamily.
    
  0.900
Tpau_1531
PFAM: PfkB domain protein; KEGG: rer:RER_36040 adenosine kinase.
    
  0.900
Tpau_2122
PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: rha:RHA1_ro07236 purine nucleosidase.
     
  0.900
Tpau_2145
PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family.
     
  0.900
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
Server load: low (26%) [HD]