Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_2767Transcription regulator of the Arc/MetJ class- like protein; KEGG: msm:MSMEG_4507 hypothetical protein. (117 aa)    
Predicted Functional Partners:
Tpau_2768
PFAM: protein of unknown function DUF541; KEGG: mab:MAB_0525c lipoprotein LpqG.
 
     0.791
disA
Protein of unknown function DUF147; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
  
     0.705
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
       0.679
Tpau_0285
KEGG: rsa:RSal33209_0055 MarR family transcriptional regulator; PFAM: regulatory protein MarR; SMART: regulatory protein MarR.
  
     0.671
Tpau_2763
KEGG: rop:ROP_09650 hypothetical protein.
 
     0.642
Tpau_2769
PFAM: protein of unknown function DUF541; KEGG: msm:MSMEG_6109 LpqG protein.
 
     0.637
Tpau_2764
Protein of unknown function DUF558; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
       0.555
dnaJ-2
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
       0.555
Tpau_2908
PFAM: Methionine synthase vitamin-B12 independent; KEGG: rer:RER_23790 hypothetical protein.
  
     0.547
Tpau_2721
KEGG: rop:ROP_09180 hypothetical protein.
  
     0.477
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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