Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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gene co-occurrence
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Tpau_2833KEGG: rer:RER_24240 ATP-dependent DNA helicase RecG; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; type III restriction protein res subunit; nucleic acid binding OB-fold tRNA/helicase-type; SMART: DEAD-like helicase; helicase domain protein. (778 aa)    
Predicted Functional Partners:
Tpau_2834
PFAM: Dak phosphatase; KEGG: rha:RHA1_ro06515 kinase related to hydroxyacetone kinase.
  
    0.914
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
  
 0.697
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.688
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
  
  
 0.675
rpmB
KEGG: nfa:nfa41960 50S ribosomal protein L28; TIGRFAM: ribosomal protein L28; PFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.
     
 0.641
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
  
 0.621
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
   
 0.619
Tpau_2968
PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; ferredoxin; molybdopterin dehydrogenase FAD-binding; [2Fe-2S]-binding domain protein; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: rha:RHA1_ro04506 xanthine dehydrogenase molybdenum binding subunit.
     
 0.619
Tpau_3046
KEGG: mab:MAB_3511c DNA helicase II; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein.
  
  
 0.607
Tpau_2686
DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: rha:RHA1_ro01126 hypothetical protein; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein.
  
  
 0.606
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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