node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tpau_1545 | Tpau_1546 | Tpau_1545 | Tpau_1546 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | 0.999 |
Tpau_1545 | Tpau_2863 | Tpau_1545 | Tpau_2863 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | KEGG: rop:ROP_65400 acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. | 0.854 |
Tpau_1545 | Tpau_2864 | Tpau_1545 | Tpau_2864 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | KEGG: rop:ROP_65390 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region. | 0.825 |
Tpau_1545 | ilvA | Tpau_1545 | Tpau_1991 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.640 |
Tpau_1545 | ilvC | Tpau_1545 | Tpau_2862 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.915 |
Tpau_1545 | leuA | Tpau_1545 | Tpau_3988 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.979 |
Tpau_1545 | leuB | Tpau_1545 | Tpau_2855 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.993 |
Tpau_1545 | leuC | Tpau_1545 | Tpau_2848 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.996 |
Tpau_1545 | leuD | Tpau_1545 | Tpau_2847 | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.921 |
Tpau_1546 | Tpau_1545 | Tpau_1546 | Tpau_1545 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | PFAM: aconitate hydratase domain protein; KEGG: syd:Syncc9605_0257 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family. | 0.999 |
Tpau_1546 | Tpau_2863 | Tpau_1546 | Tpau_2863 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | KEGG: rop:ROP_65400 acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. | 0.721 |
Tpau_1546 | Tpau_2864 | Tpau_1546 | Tpau_2864 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | KEGG: rop:ROP_65390 acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region. | 0.674 |
Tpau_1546 | ilvA | Tpau_1546 | Tpau_1991 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.490 |
Tpau_1546 | ilvC | Tpau_1546 | Tpau_2862 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.858 |
Tpau_1546 | leuA | Tpau_1546 | Tpau_3988 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.979 |
Tpau_1546 | leuB | Tpau_1546 | Tpau_2855 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.995 |
Tpau_1546 | leuC | Tpau_1546 | Tpau_2848 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.906 |
Tpau_1546 | leuD | Tpau_1546 | Tpau_2847 | PFAM: aconitate hydratase domain protein; KEGG: scl:sce0086 isopropylmalate isomerase large subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.999 |
Tpau_2856 | Tpau_2863 | Tpau_2856 | Tpau_2863 | KEGG: rha:RHA1_ro06489 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. | KEGG: rop:ROP_65400 acetolactate synthase small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. | 0.539 |
Tpau_2856 | ilvC | Tpau_2856 | Tpau_2862 | KEGG: rha:RHA1_ro06489 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.570 |