Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Score
Tpau_2892PFAM: bifunctional deaminase-reductase domain protein; KEGG: mkm:Mkms_0225 deaminase-reductase domain- containing protein. (181 aa)    
Predicted Functional Partners:
Tpau_2893
SMART: Helix-turn-helix, AraC domain; KEGG: mkm:Mkms_0224 AraC family transcriptional regulator.
 
     0.920
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.865
Tpau_3158
PFAM: bifunctional deaminase-reductase domain protein; KEGG: sco:SCO2813 hypothetical protein.
  
     0.670
Tpau_2894
PFAM: regulatory protein TetR; KEGG: rha:RHA1_ro05317 TetR family transcriptional regulator.
       0.620
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.551
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.524
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
    
 0.519
Tpau_1469
TIGRFAM: FolC bifunctional protein; KEGG: nfa:nfa13490 putative folylpolyglutamate synthetase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein.
     
 0.518
Tpau_2890
PFAM: alpha/beta hydrolase fold; KEGG: bur:Bcep18194_C6846 alpha/beta hydrolase.
       0.496
Tpau_2891
KEGG: mab:MAB_2654 putative monooxygenase.
       0.496
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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