Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Tpau_2946KEGG: nfa:nfa13650 hypothetical protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (314 aa)    
Predicted Functional Partners:
Tpau_4039
PFAM: ATP dependent DNA ligase; KEGG: rop:ROP_51680 ATP-dependent DNA ligase LigC.
   
 0.972
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.872
Tpau_2945
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: rer:RER_56310 ferredoxin--NADP(+) reductase.
       0.762
Tpau_3810
KEGG: rha:RHA1_ro01648 ATP-dependent DNA ligase; TIGRFAM: DNA ligase I, ATP-dependent Dnl1; PFAM: ATP dependent DNA ligase; DNA ligase domain protein; ATP dependent DNA ligase domain protein.
   
 0.758
Tpau_2947
PFAM: carbonic anhydrase; KEGG: rer:RER_23060 hypothetical protein.
       0.590
Tpau_2944
KEGG: mab:MAB_0929 hypothetical protein.
       0.538
Tpau_2173
KEGG: rop:ROP_05710 putative 5'-3' exonuclease; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2.
  
   
 0.406
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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