Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_3151KEGG: rha:RHA1_ro05845 cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase. (390 aa)    
Predicted Functional Partners:
Tpau_3152
TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; KEGG: rop:ROP_59040 cystathionine beta-synthase; SMART: CBS domain containing protein.
 
 0.998
Tpau_2144
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.972
Tpau_2771
KEGG: rop:ROP_09710 sulfite reductase; PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein.
  
 
 0.959
Tpau_0695
PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: rha:RHA1_ro02027 cysteine synthase.
  
 0.948
metXA
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
  
 0.947
Tpau_3390
TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: rer:RER_20030 O-acetylhomoserine (thiol)- lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase.
 
 
0.934
Tpau_1381
PFAM: molybdopterin oxidoreductase; flavodoxin/nitric oxide synthase; FAD-binding domain protein; molybdopterin oxidoreductase Fe4S4 region; oxidoreductase FAD/NAD(P)-binding domain protein; molydopterin dinucleotide-binding region; KEGG: ppw:PputW619_1259 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
  
 
 0.930
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.921
Tpau_1524
KEGG: mab:MAB_1950 branched-chain amino acid aminotransferase (IlvE); TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV.
   
 0.921
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
  
0.919
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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