Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
Tpau_3349KEGG: msm:MSMEG_5545 formamidopyrimidine-DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; DNA glycosylase/AP lyase, H2TH DNA- binding; Belongs to the FPG family. (290 aa)    
Predicted Functional Partners:
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
0.927
Tpau_0588
PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; KEGG: rer:RER_20980 DNA glycosylase.
  
   
 0.846
Tpau_3350
PFAM: inositol monophosphatase; KEGG: cgt:cgR_0960 hypothetical protein.
       0.636
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.604
Tpau_3351
SMART: Helix-turn-helix, AraC domain; KEGG: nfa:pnf1370 putative DNA-binding protein.
       0.572
Tpau_3347
Dyp-type peroxidase family; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family.
       0.568
Tpau_3348
PFAM: iron permease FTR1; Peptidase M75, Imelysin; KEGG: mab:MAB_1159 putative iron permease FTR1.
       0.568
Tpau_2686
DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: rha:RHA1_ro01126 hypothetical protein; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein.
  
  
 0.541
Tpau_4039
PFAM: ATP dependent DNA ligase; KEGG: rop:ROP_51680 ATP-dependent DNA ligase LigC.
 
   
 0.516
Tpau_3342
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: nfa:nfa43220 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.510
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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