Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Tpau_3499KEGG: nca:Noca_1780 D-amino-acid oxidase; PFAM: FAD dependent oxidoreductase. (305 aa)    
Predicted Functional Partners:
Tpau_1417
Agmatinase; KEGG: rer:RER_05760 agmatinase; TIGRFAM: agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family.
 
 
 0.927
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.911
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.908
Tpau_0921
KEGG: mlu:Mlut_01000 L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase.
    
 0.905
Tpau_0992
Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: nfa:nfa9700 putative aminotransferase.
     
 0.900
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
  
 
 0.815
Tpau_1211
2-oxoglutarate dehydrogenase, E1 subunit; KEGG: rha:RHA1_ro06012 alpha-ketoglutarate decarboxylase; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes.
   
 
 0.814
Tpau_3500
Transcriptional regulator, TetR family; PFAM: regulatory protein TetR; KEGG: fal:FRAAL0421 putative regulatory protein.
 
     0.813
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
     
 0.807
Tpau_0177
D-lactate dehydrogenase (cytochrome); KEGG: rer:RER_51320 FAD-linked oxidase; PFAM: FAD linked oxidase domain protein.
     
 0.803
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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