Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Tpau_4038PFAM: DNA primase small subunit; KEGG: nca:Noca_3665 hypothetical protein. (364 aa)    
Predicted Functional Partners:
Tpau_4039
PFAM: ATP dependent DNA ligase; KEGG: rop:ROP_51680 ATP-dependent DNA ligase LigC.
   
 0.994
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.871
Tpau_3810
KEGG: rha:RHA1_ro01648 ATP-dependent DNA ligase; TIGRFAM: DNA ligase I, ATP-dependent Dnl1; PFAM: ATP dependent DNA ligase; DNA ligase domain protein; ATP dependent DNA ligase domain protein.
 
   
 0.726
Tpau_4040
PFAM: protein of unknown function DUF664; KEGG: nfa:nfa32260 hypothetical protein.
       0.584
gluQ
Glutamate--tRNA ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
  
    0.439
Tpau_4041
PFAM: Helix-turn-helix type 11 domain protein; regulatory protein DeoR; KEGG: nfa:nfa32250 putative transcriptional regulator.
       0.428
Tpau_2173
KEGG: rop:ROP_05710 putative 5'-3' exonuclease; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2.
  
   
 0.413
Your Current Organism:
Tsukamurella paurometabola
NCBI taxonomy Id: 521096
Other names: T. paurometabola DSM 20162, Tsukamurella paurometabola ATCC 8368, Tsukamurella paurometabola DSM 20162, Tsukamurella paurometabola str. DSM 20162, Tsukamurella paurometabola strain DSM 20162
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