| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Tpau_2155 | Tpau_2159 | Tpau_2155 | Tpau_2159 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.842 |
| Tpau_2155 | Tpau_2160 | Tpau_2155 | Tpau_2160 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.836 |
| Tpau_2155 | Tpau_4099 | Tpau_2155 | Tpau_4099 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | PFAM: Protein of unknown function DUF2587; KEGG: rer:RER_02610 hypothetical protein. | 0.684 |
| Tpau_2155 | arc | Tpau_2155 | Tpau_2153 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.944 |
| Tpau_2155 | pafA | Tpau_2155 | Tpau_2166 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.412 |
| Tpau_2155 | pup | Tpau_2155 | Tpau_2158 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.856 |
| Tpau_2159 | Tpau_2155 | Tpau_2159 | Tpau_2155 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | 0.842 |
| Tpau_2159 | Tpau_2160 | Tpau_2159 | Tpau_2160 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.999 |
| Tpau_2159 | Tpau_4099 | Tpau_2159 | Tpau_4099 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | PFAM: Protein of unknown function DUF2587; KEGG: rer:RER_02610 hypothetical protein. | 0.927 |
| Tpau_2159 | arc | Tpau_2159 | Tpau_2153 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.978 |
| Tpau_2159 | pafA | Tpau_2159 | Tpau_2166 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.902 |
| Tpau_2159 | pup | Tpau_2159 | Tpau_2158 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.963 |
| Tpau_2160 | Tpau_2155 | Tpau_2160 | Tpau_2155 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: rop:ROP_05840 putative proteasome accessory factor. | 0.836 |
| Tpau_2160 | Tpau_2159 | Tpau_2160 | Tpau_2159 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.999 |
| Tpau_2160 | Tpau_4099 | Tpau_2160 | Tpau_4099 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | PFAM: Protein of unknown function DUF2587; KEGG: rer:RER_02610 hypothetical protein. | 0.980 |
| Tpau_2160 | arc | Tpau_2160 | Tpau_2153 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.991 |
| Tpau_2160 | pafA | Tpau_2160 | Tpau_2166 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.943 |
| Tpau_2160 | pup | Tpau_2160 | Tpau_2158 | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.966 |
| Tpau_4098 | Tpau_4099 | Tpau_4098 | Tpau_4099 | KEGG: mjl:Mjls_5370 cysteine desulfurase family protein; TIGRFAM: cysteine desulfurase family protein; PFAM: aminotransferase class V. | PFAM: Protein of unknown function DUF2587; KEGG: rer:RER_02610 hypothetical protein. | 0.679 |
| Tpau_4098 | Tpau_4100 | Tpau_4098 | Tpau_4100 | KEGG: mjl:Mjls_5370 cysteine desulfurase family protein; TIGRFAM: cysteine desulfurase family protein; PFAM: aminotransferase class V. | PFAM: ABC-2 type transporter; KEGG: cdi:DIP0175 ABC transporter permease. | 0.663 |
