| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Coch_0409 | Coch_0411 | Coch_0409 | Coch_0411 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | 0.999 |
| Coch_0409 | Coch_0413 | Coch_0409 | Coch_0413 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | KEGG: gfo:GFO_0334 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.971 |
| Coch_0409 | Coch_0944 | Coch_0409 | Coch_0944 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: fnu:FN1411 threonine dehydratase. | 0.971 |
| Coch_0409 | Coch_1685 | Coch_0409 | Coch_1685 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: cac:CAC0390 cystathionine gamma-synthase. | 0.905 |
| Coch_0409 | Coch_1829 | Coch_0409 | Coch_1829 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gfo:GFO_1794 cysteine synthase/cystathionine beta-synthase. | 0.889 |
| Coch_0409 | Coch_2102 | Coch_0409 | Coch_2102 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: gfo:GFO_0587 CDP-diacylglycerol-serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.800 |
| Coch_0409 | Coch_2109 | Coch_0409 | Coch_2109 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | KEGG: fjo:Fjoh_4709 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.862 |
| Coch_0409 | asd | Coch_0409 | Coch_1863 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.927 |
| Coch_0409 | glyA | Coch_0409 | Coch_1617 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
| Coch_0409 | metE | Coch_0409 | Coch_1731 | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | 5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.840 |
| Coch_0411 | Coch_0409 | Coch_0411 | Coch_0409 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | 0.999 |
| Coch_0411 | Coch_0413 | Coch_0411 | Coch_0413 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | KEGG: gfo:GFO_0334 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.971 |
| Coch_0411 | Coch_0944 | Coch_0411 | Coch_0944 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: fnu:FN1411 threonine dehydratase. | 0.863 |
| Coch_0411 | Coch_1685 | Coch_0411 | Coch_1685 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: cac:CAC0390 cystathionine gamma-synthase. | 0.975 |
| Coch_0411 | Coch_1829 | Coch_0411 | Coch_1829 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gfo:GFO_1794 cysteine synthase/cystathionine beta-synthase. | 0.889 |
| Coch_0411 | Coch_2109 | Coch_0411 | Coch_2109 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | KEGG: fjo:Fjoh_4709 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.862 |
| Coch_0411 | asd | Coch_0411 | Coch_1863 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.994 |
| Coch_0411 | glyA | Coch_0411 | Coch_1617 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.664 |
| Coch_0411 | metE | Coch_0411 | Coch_1731 | KEGG: fjo:Fjoh_1494 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. | 5-methyltetrahydropteroyltriglutamate/homocystei neS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.966 |
| Coch_0413 | Coch_0409 | Coch_0413 | Coch_0409 | KEGG: gfo:GFO_0334 methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: alpha/beta hydrolase fold; KEGG: fps:FP0256 homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | 0.971 |