Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Coch_0685KEGG: tde:TDE0910 hypothetical protein. (571 aa)    
Predicted Functional Partners:
Coch_0441
KEGG: fjo:Fjoh_2475 DNA topoisomerase IV subunit A; PFAM: DNA gyrase/topoisomerase IV subunit A; SMART: DNA gyrase/topoisomerase IV subunit A.
  
 
 0.812
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 
 0.812
Coch_0684
KEGG: cts:Ctha_1153 DNA methylase N-4/N-6 domain protein.
 
     0.801
Coch_0686
KEGG: cch:Cag_0333 type II restriction endonuclease TdeIII.
 
     0.799
Coch_0687
PFAM: glycosidase PH1107-related; KEGG: fjo:Fjoh_2034 glycosidase, PH1107-related.
       0.773
Coch_0683
Hypothetical protein.
       0.696
Coch_0681
KEGG: chy:CHY_2514 hypothetical protein.
       0.677
Coch_0682
KEGG: csc:Csac_2581 hypothetical protein.
       0.677
Coch_1947
PFAM: helicase domain protein; type III restriction protein res subunit; SMART: helicase domain protein; DEAD-like helicases; KEGG: pmo:Pmob_1535 helicase domain-containing protein.
  
 
 0.648
Coch_0680
PFAM: restriction endonuclease; KEGG: mhu:Mhun_0477 restriction endonuclease.
       0.630
Your Current Organism:
Capnocytophaga ochracea
NCBI taxonomy Id: 521097
Other names: C. ochracea DSM 7271, Capnocytophaga ochracea ATCC 27872, Capnocytophaga ochracea DSM 7271, Capnocytophaga ochracea str. DSM 7271, Capnocytophaga ochracea strain DSM 7271
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