Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Coch_2083PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; KEGG: fps:FP0646 DNA topoisomerase IV subunit B. (616 aa)    
Predicted Functional Partners:
Coch_0441
KEGG: fjo:Fjoh_2475 DNA topoisomerase IV subunit A; PFAM: DNA gyrase/topoisomerase IV subunit A; SMART: DNA gyrase/topoisomerase IV subunit A.
 
 
 0.973
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 
 0.957
Coch_2084
PFAM: Polyprenyl synthetase; KEGG: fps:FP2078 polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
   
 
 0.789
Coch_1947
PFAM: helicase domain protein; type III restriction protein res subunit; SMART: helicase domain protein; DEAD-like helicases; KEGG: pmo:Pmob_1535 helicase domain-containing protein.
  
 
 0.648
Coch_2085
PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase; KEGG: gfo:GFO_0767 shikimate 5-dehydrogenase.
     
 0.603
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
 
 
 0.585
Coch_2082
KEGG: syp:SYNPCC7002_A0598 hypothetical protein.
  
  
 0.571
argS
KEGG: fjo:Fjoh_0251 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase.
  
  
 0.554
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.525
secD
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
 
  
 0.490
Your Current Organism:
Capnocytophaga ochracea
NCBI taxonomy Id: 521097
Other names: C. ochracea DSM 7271, Capnocytophaga ochracea ATCC 27872, Capnocytophaga ochracea DSM 7271, Capnocytophaga ochracea str. DSM 7271, Capnocytophaga ochracea strain DSM 7271
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