| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Coch_0174 | Coch_1032 | Coch_0174 | Coch_1032 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.607 |
| Coch_0174 | Coch_1530 | Coch_0174 | Coch_1530 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | 0.619 |
| Coch_0174 | Coch_2108 | Coch_0174 | Coch_2108 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: fps:FP1425 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS. | 0.609 |
| Coch_0174 | folE | Coch_0174 | Coch_0055 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: fjo:Fjoh_2270 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I. | 0.634 |
| Coch_0174 | guaB | Coch_0174 | Coch_0015 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.922 |
| Coch_1032 | Coch_0174 | Coch_1032 | Coch_0174 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.607 |
| Coch_1032 | Coch_1530 | Coch_1032 | Coch_1530 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | 0.965 |
| Coch_1032 | Coch_1979 | Coch_1032 | Coch_1979 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | KEGG: fjo:Fjoh_0461 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein. | 0.685 |
| Coch_1032 | Coch_2108 | Coch_1032 | Coch_2108 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | KEGG: fps:FP1425 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS. | 0.994 |
| Coch_1032 | folE | Coch_1032 | Coch_0055 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | KEGG: fjo:Fjoh_2270 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I. | 0.939 |
| Coch_1530 | Coch_0174 | Coch_1530 | Coch_0174 | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.619 |
| Coch_1530 | Coch_1032 | Coch_1530 | Coch_1032 | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.965 |
| Coch_1530 | Coch_1979 | Coch_1530 | Coch_1979 | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | KEGG: fjo:Fjoh_0461 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein. | 0.764 |
| Coch_1530 | Coch_2108 | Coch_1530 | Coch_2108 | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | KEGG: fps:FP1425 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS. | 0.995 |
| Coch_1530 | folE | Coch_1530 | Coch_0055 | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | KEGG: fjo:Fjoh_2270 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I. | 0.952 |
| Coch_1979 | Coch_1032 | Coch_1979 | Coch_1032 | KEGG: fjo:Fjoh_0461 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.685 |
| Coch_1979 | Coch_1530 | Coch_1979 | Coch_1530 | KEGG: fjo:Fjoh_0461 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein. | TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; deoxynucleoside kinase; KEGG: gfo:GFO_0246 protein containing HppK and dNK domain. | 0.764 |
| Coch_1979 | Coch_2108 | Coch_1979 | Coch_2108 | KEGG: fjo:Fjoh_0461 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein. | KEGG: fps:FP1425 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS. | 0.998 |
| Coch_1979 | folE | Coch_1979 | Coch_0055 | KEGG: fjo:Fjoh_0461 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein. | KEGG: fjo:Fjoh_2270 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I. | 0.702 |
| Coch_2108 | Coch_0174 | Coch_2108 | Coch_0174 | KEGG: fps:FP1425 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.609 |