| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Coch_0515 | Coch_0918 | Coch_0515 | Coch_0918 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.540 |
| Coch_0515 | gmk | Coch_0515 | Coch_2168 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.557 |
| Coch_0515 | nadD | Coch_0515 | Coch_2169 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.694 |
| Coch_0515 | nadK | Coch_0515 | Coch_0669 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.405 |
| Coch_0515 | pncB | Coch_0515 | Coch_0338 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.422 |
| Coch_0918 | Coch_0515 | Coch_0918 | Coch_0515 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.540 |
| Coch_0918 | cobB | Coch_0918 | Coch_1968 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | PFAM: Silent information regulator protein Sir2; KEGG: fjo:Fjoh_5013 silent information regulator protein Sir2; Belongs to the sirtuin family. Class III subfamily. | 0.917 |
| Coch_0918 | nadD | Coch_0918 | Coch_2169 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.940 |
| Coch_0918 | nadK | Coch_0918 | Coch_0669 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.935 |
| Coch_0918 | pncB | Coch_0918 | Coch_0338 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.610 |
| Coch_1793 | gmk | Coch_1793 | Coch_2168 | PFAM: metallophosphoesterase; KEGG: fjo:Fjoh_3473 metallophosphoesterase; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.902 |
| Coch_1793 | nadD | Coch_1793 | Coch_2169 | PFAM: metallophosphoesterase; KEGG: fjo:Fjoh_3473 metallophosphoesterase; Belongs to the 5'-nucleotidase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.906 |
| Coch_1793 | pncB | Coch_1793 | Coch_0338 | PFAM: metallophosphoesterase; KEGG: fjo:Fjoh_3473 metallophosphoesterase; Belongs to the 5'-nucleotidase family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.902 |
| Coch_1793 | surE | Coch_1793 | Coch_1351 | PFAM: metallophosphoesterase; KEGG: fjo:Fjoh_3473 metallophosphoesterase; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.906 |
| Coch_2167 | gmk | Coch_2167 | Coch_2168 | PFAM: domain of unknown function DUF1732; YicC domain protein; KEGG: gfo:GFO_3433 hypothetical protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.894 |
| Coch_2167 | nadD | Coch_2167 | Coch_2169 | PFAM: domain of unknown function DUF1732; YicC domain protein; KEGG: gfo:GFO_3433 hypothetical protein. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.781 |
| cobB | Coch_0918 | Coch_1968 | Coch_0918 | PFAM: Silent information regulator protein Sir2; KEGG: fjo:Fjoh_5013 silent information regulator protein Sir2; Belongs to the sirtuin family. Class III subfamily. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.917 |
| cobB | nadD | Coch_1968 | Coch_2169 | PFAM: Silent information regulator protein Sir2; KEGG: fjo:Fjoh_5013 silent information regulator protein Sir2; Belongs to the sirtuin family. Class III subfamily. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.924 |
| cobB | nadK | Coch_1968 | Coch_0669 | PFAM: Silent information regulator protein Sir2; KEGG: fjo:Fjoh_5013 silent information regulator protein Sir2; Belongs to the sirtuin family. Class III subfamily. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.914 |
| gmk | Coch_0515 | Coch_2168 | Coch_0515 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.557 |