STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Athe_0787RNA polymerase, sigma 28 subunit, SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (244 aa)    
Predicted Functional Partners:
Athe_0784
Peptidase U4 sporulation factor SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
 
  
 0.884
Athe_1337
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.842
Athe_0628
TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain protein; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein.
 
     0.825
Athe_0646
KEGG: csc:Csac_1212 hypothetical protein.
  
    0.802
Athe_1006
TIGRFAM: stage V sporulation protein T; transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein; KEGG: csc:Csac_2118 AbrB family transcriptional regulator.
  
    0.802
Athe_1953
KEGG: csc:Csac_0999 hypothetical protein.
 
     0.800
Athe_2601
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
    0.781
Athe_1336
TIGRFAM: stage IV sporulation protein B; PFAM: peptidase S55 SpoIVB; KEGG: csc:Csac_1899 peptidase S55, SpoIVB.
  
     0.774
Athe_2731
TIGRFAM: stage V sporulation protein AC; PFAM: SpoVA protein; KEGG: csc:Csac_0092 SpoVA protein.
  
     0.774
Athe_2732
TIGRFAM: stage V sporulation protein AD; PFAM: Stage V sporulation AD family protein; KEGG: csc:Csac_0091 stage V sporulation protein AD.
  
     0.774
Your Current Organism:
Caldicellulosiruptor bescii
NCBI taxonomy Id: 521460
Other names: Anaerocellum thermophilum DSM 6725, C. bescii DSM 6725, Caldicellulosiruptor becscii str. DSM 6725, Caldicellulosiruptor bescii DSM 6725, Caldicellulosiruptor bescii strain DSM 6725
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.