node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Athe_0564 | Athe_1214 | Athe_0564 | Athe_1214 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: csc:Csac_1779 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | 0.576 |
Athe_0564 | nadD | Athe_0564 | Athe_1250 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.807 |
Athe_0564 | nadE | Athe_0564 | Athe_0223 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.705 |
Athe_0564 | nadK | Athe_0564 | Athe_1333 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.400 |
Athe_1123 | Athe_1251 | Athe_1123 | Athe_1251 | PFAM: protein of unknown function UPF0044; KEGG: csc:Csac_1573 hypothetical protein. | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: csc:Csac_1816 metal dependent phosphohydrolase. | 0.609 |
Athe_1123 | aroE | Athe_1123 | Athe_1889 | PFAM: protein of unknown function UPF0044; KEGG: csc:Csac_1573 hypothetical protein. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.515 |
Athe_1123 | nadD | Athe_1123 | Athe_1250 | PFAM: protein of unknown function UPF0044; KEGG: csc:Csac_1573 hypothetical protein. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.787 |
Athe_1123 | rsfS | Athe_1123 | Athe_1253 | PFAM: protein of unknown function UPF0044; KEGG: csc:Csac_1573 hypothetical protein. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.631 |
Athe_1214 | Athe_0564 | Athe_1214 | Athe_0564 | KEGG: csc:Csac_1779 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.576 |
Athe_1214 | cinA | Athe_1214 | Athe_0985 | KEGG: csc:Csac_1779 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; KEGG: csc:Csac_2139 competence/damage-inducible protein CinA; Belongs to the CinA family. | 0.956 |
Athe_1214 | nadD | Athe_1214 | Athe_1250 | KEGG: csc:Csac_1779 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.946 |
Athe_1214 | nadE | Athe_1214 | Athe_0223 | KEGG: csc:Csac_1779 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.683 |
Athe_1251 | Athe_1123 | Athe_1251 | Athe_1123 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: csc:Csac_1816 metal dependent phosphohydrolase. | PFAM: protein of unknown function UPF0044; KEGG: csc:Csac_1573 hypothetical protein. | 0.609 |
Athe_1251 | Athe_1252 | Athe_1251 | Athe_1252 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: csc:Csac_1816 metal dependent phosphohydrolase. | TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator; KEGG: csc:Csac_1817 cell envelope-related transcriptional attenuator. | 0.866 |
Athe_1251 | aroE | Athe_1251 | Athe_1889 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: csc:Csac_1816 metal dependent phosphohydrolase. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.546 |
Athe_1251 | nadD | Athe_1251 | Athe_1250 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: csc:Csac_1816 metal dependent phosphohydrolase. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.997 |
Athe_1251 | rsfS | Athe_1251 | Athe_1253 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: csc:Csac_1816 metal dependent phosphohydrolase. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.944 |
Athe_1252 | Athe_1251 | Athe_1252 | Athe_1251 | TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator; KEGG: csc:Csac_1817 cell envelope-related transcriptional attenuator. | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: csc:Csac_1816 metal dependent phosphohydrolase. | 0.866 |
Athe_1252 | nadD | Athe_1252 | Athe_1250 | TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator; KEGG: csc:Csac_1817 cell envelope-related transcriptional attenuator. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.850 |
Athe_1252 | rsfS | Athe_1252 | Athe_1253 | TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator; KEGG: csc:Csac_1817 cell envelope-related transcriptional attenuator. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.784 |