STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Athe_2647PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: tte:TTE1073 biotin synthase. (351 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.984
Athe_0473
TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; Miro domain protein; KEGG: csc:Csac_1123 small GTP-binding protein.
   
 0.977
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
 
 0.956
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
  0.919
Athe_1299
TIGRFAM: hydrogenase, Fe-only; PFAM: hydrogenase large subunit domain protein; iron hydrogenase small subunit; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_1864 hydrogenase, Fe-only.
 
  
 0.875
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
  
 0.803
Athe_0168
KEGG: csc:Csac_2425 CopG family transcriptional regulator.
 
  
 0.794
Athe_2207
PFAM: aminotransferase class I and II; glycine hydroxymethyltransferase; aminotransferase class-III; Orn/Lys/Arg decarboxylase major region; aminotransferase class V; Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: csc:Csac_1225 glycine C-acetyltransferase.
  
  
 0.693
Athe_2646
KEGG: csc:Csac_0492 hypothetical protein.
       0.535
Athe_2648
TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: csc:Csac_0490 1A family penicillin-binding protein.
       0.505
Your Current Organism:
Caldicellulosiruptor bescii
NCBI taxonomy Id: 521460
Other names: Anaerocellum thermophilum DSM 6725, C. bescii DSM 6725, Caldicellulosiruptor becscii str. DSM 6725, Caldicellulosiruptor bescii DSM 6725, Caldicellulosiruptor bescii strain DSM 6725
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