STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Plim_0079PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mca:MCA3071 isocitrate dehydrogenase, NAD- dependent, putative. (389 aa)    
Predicted Functional Partners:
Plim_2285
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.950
Plim_0622
TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; KEGG: scl:sce5670 alpha-ketoglutarate decarboxylase.
   
 0.919
Plim_2694
Glutamate synthase (NADH).
  
 
 0.894
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.873
Plim_0321
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
 0.866
argH
TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: hypothetical protein; K01755 argininosuccinate lyase.
  
 
 0.844
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.830
Plim_1192
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: sfu:Sfum_3022 acetolactate synthase, small subunit.
  
 
 0.825
Plim_1474
PFAM: Aldehyde Dehydrogenase; KEGG: xca:xccb100_1755 aldehyde dehydrogenase (NADP(+)).
   
 0.813
Plim_1227
PFAM: pyruvate carboxyltransferase; KEGG: dvl:Dvul_0391 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.812
Your Current Organism:
Planctopirus limnophila
NCBI taxonomy Id: 521674
Other names: P. limnophila DSM 3776, Planctomyces limnophilus ATCC 43296, Planctomyces limnophilus DSM 3776, Planctomyces limnophilus str. DSM 3776, Planctomyces limnophilus strain DSM 3776, Planctopirus limnophila DSM 3776, Planctopirus limnophilus DSM 3776
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